Copeland has used his expertise as director of enzymology at Dupont Chemicals (he's also affiliated with U. of Pennsylvania School of Medicine) to produce an introductory textbook intended for senior undergraduate or graduate students. After a brief history of enzymology, coverage includes chemical bonds and reactions, structural components of enzymes, protein-ligand binding equilibria, kinetics of single and multiple substrate enzyme reactions, chemical mechanisms, experimental measures, inhibitors, and cooperativity.