Intended for graduate students and researchers familiar with basic probabilistic concepts and statistical methods, this textbook gathers spatial statistical ideas developed in a broad variety of areas and discusses them in the context of routinely occurring spatial questions in public health. Waller (biostatistics, Emory University) and Gotway (Centers for Disease Control) introduce statistical methods for the analysis of spatial point patterns, extend them to identifying disease clusters, and outline methods for regression modeling using spatially referenced exposure and disease data.