A range of medical and biological sciences, including occupational health and pharmacology are represented by the contributors. They review issues of molecular and cellular biology as well as clinical aspects of environmental oxidants and their effects on target organs. After looking at the basic pathology induced by pro-oxidant environmental xenobiotic they consider lungs, skin, and eyes as target organs of environmental oxidants. Among specific topics are the role of oxidative stress in chemical carcinogenesis, cigarette smoking and pulmonary oxidative damage, ozone stress in the skin barrier, and the role of ocular free radicals in age-related macular degeneration.