Bioinorganic chemistry has a cross disciplinary approach, applying the principles of chemistry to biological systems. Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects discusses the rapidly developing area of metals in the nervous system and their role in neurodegenerative disease, such as Alzheimer's, Parkinson's and prion diseases.
Written by leading experts in their fields, each chapter combines elements of genetics, biochemistry and biological inorganic chemistry in its discussion. The book highlights the differences in pathologies of neurodegenerative diseases but also discusses the mechanistic similarities. Sections include: metal ions and prion diseases; metal ions and Alzheimer disease; manganese in brain functioning; metal involvement in Parkinson disease; Cu-Zn superoxide dismutase and familial amyotrophic lateral sclerosis.
This book will appeal to both chemists and biologists at the postgraduate and research level.
From a review by Dennis Rouvray in Chemistry World, April 2007
This book sets itself the task of elucidating the behavior of proteins in the brain, in particular exploring the joint impacts of metal ions and oxidative stress on protein folding. The level is appropriate primarily for research workers in the field although I feel that most chemists should be able to read this work with profit.
… this book is scientifically sound and surprisingly wide-ranging in its coverage ... a worthwhile addition to the rather sparse literature on the subject.
