Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity * examines metal compounds that cleave DNA, their design, and mechanisms of action * explores future applications for targeting site-specific DNA cleavage agents * presents developments in DNA-binding zinc-finger protein, its DNA recognition, metal replacement, and structure and function * delineates gene regulation by metals * furnishes over 1200 bibliographic citations and some 200 drawings, tables, photographs, x-rays, and micrographs to assist research and aid more in-depth study of topics * and more.