The role of innovations and clusters has increasingly dominated local and regional development policies in recent decades. This authoritative and accessible Handbook considers important aspects of high-tech clusters, analyses insightful cluster case studies, and provides a number of recommendations for cluster policies. The chapters in this Handbook are written by international experts in the field and present evidence of the scope, effects, and potential of clusters as concentrations of innovative activities. The authors emphasize that cluster development is not the only option for local and regional development and argue that for cluster policies to be worthwhile, supporting policies in fields such as education, R&D, transportation, and communication infrastructure must accompany most cluster policies.Furthermore, several contributions stress that clusters often develop along a life cycle that may end with decline and even the disappearance of clusters. Consequently, this Handbook provides the basis for improving both research on innovation and clusters and the formulation and implementation of cluster policies. Furnishing the reader with rich, comprehensive discussion of innovations and clusters, this Handbook will be an essential source for researchers and academics in the field, as well as policymakers, planners and specialists, development experts and agencies, and consultants.